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Curr Biol. 2000 Nov 2;10(21):R801-3.

Cytoskeleton: functions for tubulin modifications at last.

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  • 1Department of Biology, Yale University, 310 Kline Biology Tower, New Haven, Connecticut 06511-8112, USA.


New studies show that three types of evolutionarily conserved post translational tubulin modification, polyglutamylation, polyglycylation and detyrosination, play important roles in vivo. These modifications appear to act by modulating the binding of molecular motors to the external surface of microtubules.

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