Friulimicins: novel lipopeptide antibiotics with peptidoglycan synthesis inhibiting activity from Actinoplanes friuliensis sp. nov. I. Taxonomic studies of the producing microorganism and fermentation

W Aretz; J Meiwes; G Seibert; G Vobis; J Wink

doi:10.7164/antibiotics.53.807

Friulimicins: novel lipopeptide antibiotics with peptidoglycan synthesis inhibiting activity from Actinoplanes friuliensis sp. nov. I. Taxonomic studies of the producing microorganism and fermentation

J Antibiot (Tokyo). 2000 Aug;53(8):807-15. doi: 10.7164/antibiotics.53.807.

Authors

W Aretz¹, J Meiwes, G Seibert, G Vobis, J Wink

Affiliation

¹ HMR Deutschland GmbH, Frankfurt am Main, Germany.

PMID: 11079803
DOI: 10.7164/antibiotics.53.807

Abstract

A strain that produces new lipopeptide antibiotics is a new species of the genus Actinoplanes for which we propose the name Actinoplanes friuliensis (type strain: HAG 010964). The strain is an actinoplanete actinomycete having cell wall II composition and forming sporangia. Comparisons with Actinoplanes spp. which have similarities with our isolate, including fatty acid analysis, showed that the isolate belongs to a new species. Taxonomic studies and fermentation are presented.

MeSH terms

Actinomycetales / classification*
Actinomycetales / metabolism*
Actinomycetales / physiology
Anti-Bacterial Agents / metabolism
Anti-Bacterial Agents / pharmacology*
Drug Evaluation, Preclinical / methods
Fatty Acids / metabolism
Fermentation
Microbial Sensitivity Tests
Peptidoglycan / biosynthesis
Peptidoglycan / drug effects
Protein Synthesis Inhibitors / metabolism
Protein Synthesis Inhibitors / pharmacology*

Substances

Anti-Bacterial Agents
Fatty Acids
Peptidoglycan
Protein Synthesis Inhibitors