Decline in antibiotic enzyme activity of neutrophils is a prognostic factor for infections in patients with myelodysplastic syndrome

Y Ito; Y Kawanishi; N Shoji; K Ohyashiki

doi:10.1086/317470

Decline in antibiotic enzyme activity of neutrophils is a prognostic factor for infections in patients with myelodysplastic syndrome

Clin Infect Dis. 2000 Nov;31(5):1292-5. doi: 10.1086/317470.

Authors

Y Ito¹, Y Kawanishi, N Shoji, K Ohyashiki

Affiliation

¹ First Department of Internal Medicine, Tokyo Medical University, Japan. yito@tokyo-med.ac.jp

PMID: 11073768
DOI: 10.1086/317470

Abstract

We used flow cytometry to measure the activities of cathepsin G and elastase. The activity of elastase in neutrophils from patients with myelodysplastic syndrome (MDS) was significantly lower than that in neutrophils from the control group (P<.001). Patients with low elastase activity were significantly susceptible to infection (P<. 05). Our study suggests that analyzing antibacterial enzymes is useful in evaluating the prognosis of patients with MDS.

MeSH terms

Acute Disease
Adult
Aged
Aged, 80 and over
Cathepsin G
Cathepsins / metabolism
Female
Humans
Leukemia, Myeloid / enzymology*
Leukemia, Myeloid / pathology
Male
Middle Aged
Myelodysplastic Syndromes / enzymology*
Myelodysplastic Syndromes / pathology
Neutrophils / cytology
Neutrophils / enzymology*
Pancreatic Elastase / metabolism
Prognosis
Serine Endopeptidases
Survival Analysis

Substances

Cathepsins
Serine Endopeptidases
CTSG protein, human
Cathepsin G
Pancreatic Elastase