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Org Lett. 2000 Nov 16;2(23):3603-6.

Facile chemoselective synthesis of dehydroalanine-containing peptides.

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  • 1Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA.

Abstract

Useful methodology is described for the synthesis of dehydroalanine residues (II) within peptides. The unnatural amino acid (Se)-phenylselenocysteine (I) can be incorporated into growing peptide chains via standard peptide synthesis procedures. Subsequent oxidative elimination affords a dehydroalanine at the desired position. The oxidation conditions are mild and tolerate functionalities commonly found in peptides, including variously protected cysteine residues. To illustrate its utility, cyclic lanthionines have been synthesized by this method.

PMID:
11073655
[PubMed - indexed for MEDLINE]

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