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Biochim Biophys Acta. 2000 Nov 15;1494(1-2):201-5.

The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.

Author information

  • 1Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA.

Abstract

The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B' were not detected by Southern blot analysis, suggesting Hsp70B/B' arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.

PMID:
11072087
[PubMed - indexed for MEDLINE]
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