Send to:

Choose Destination
See comment in PubMed Commons below
Biochim Biophys Acta. 2000 Nov 15;1494(1-2):201-5.

The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.

Author information

  • 1Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA.


The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B' were not detected by Southern blot analysis, suggesting Hsp70B/B' arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk