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Neurology. 2000 Oct 24;55(8):1213-5.

Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia?

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  • 1Neurologische Klinik, Friedrich-Alexander-Universität Erlangen, Germany. birklein@physiologie1.uni-erlangen.de


To investigate oxygen metabolism in complex regional pain syndrome (CRPS), the authors measured skin lactate via dermal microdialysis performed on patients with CRPS (n = 11) and healthy control subjects (n = 11). In addition, they measured blood lactate. Although venous lactate was unaltered, skin lactate was increased in patients with CRPS (2.95 mmol/L; control subjects 1.74 mmol/L; p < 0.005). These results suggest enhanced anaerobic glycolysis, probably as a result of chronic tissue hypoxia.

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