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Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4.

Effects of environmental enrichment on gene expression in the brain.

Author information

  • 1Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121; and the Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Abstract

An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 306-307]. To better understand the molecular mechanisms underlying these experience-dependent cognitive changes, we have used high-density oligonucleotide microarrays to analyze gene expression in the brain. Expression of a large number of genes changes in response to enrichment training, many of which can be linked to neuronal structure, synaptic plasticity, and transmission. A number of these genes may play important roles in modulating learning and memory capacity.

PMID:
11070096
[PubMed - indexed for MEDLINE]
PMCID:
PMC18858
Free PMC Article
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