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Curr Biol. 2000 Oct 19;10(20):R757-9.

Metabolic control: a new solution to an old problem.

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  • 1Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Scotland, UK.


The phenomenon whereby the presence of oxygen regulates the rate of glucose metabolism was first described by Louis Pasteur. A novel mechanism has now been discovered, involving the AMP-activated protein kinase cascade, that can account for the Pasteur effect in ischaemic heart muscle.

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