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Mt Sinai J Med. 2000 Oct-Nov;67(5-6):437-43.

The impact of hepatitis C virus infection on methadone maintenance treatment.

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  • 1Digestive Specialists, Inc., Kettering Medical Center, OH 45429, USA.


Hepatitis C virus infection is now recognized as a common and serious complication of injection drug use and will be encountered frequently in methadone maintenance patients. Approximately 1.8% of the United States population, or 3.9 million persons, are infected with hepatitis C virus. A majority of acute hepatitis C virus infections are associated with injection drug use, and 64-88% of injection drug users in seroprevalence studies have antibodies to hepatitis C. Hepatitis C virus infection is almost always chronic, and alcohol use increases the clinical severity. Therapy with interferon and ribavirin will induce long-term remission in up to 43% of patients with hepatitis C virus infection. Proper diagnosis and treatment of hepatitis C virus infection will be indicated for many patients in methadone programs and will require considerable resources.

[PubMed - indexed for MEDLINE]
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