Nat Genet. 2000 Nov;26(3):358-61.

Y chromosome sequence variation and the history of human populations.

Source

Department of Genetics, Stanford University, Stanford, California, USA.under@stanford.edu

Abstract

Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history. We used denaturing high-performance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.

Comment in

Nat Genet. 2000 Nov;26(3):253-4.

PMID:: 11062480; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations. [Ann Hum Genet. 2001]
The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations.
Underhill PA, Passarino G, Lin AA, Shen P, Mirazón Lahr M, Foley RA, Oefner PJ, Cavalli-Sforza LL. Ann Hum Genet. 2001 Jan; 65(Pt 1):43-62.
Maori origins, Y-chromosome haplotypes and implications for human history in the Pacific. [Hum Mutat. 2001]
Maori origins, Y-chromosome haplotypes and implications for human history in the Pacific.
Underhill PA, Passarino G, Lin AA, Marzuki S, Oefner PJ, Cavalli-Sforza LL, Chambers GK. Hum Mutat. 2001 Apr; 17(4):271-80.
Hierarchical patterns of global human Y-chromosome diversity. [Mol Biol Evol. 2001]
Hierarchical patterns of global human Y-chromosome diversity.
Hammer MF, Karafet TM, Redd AJ, Jarjanazi H, Santachiara-Benerecetti S, Soodyall H, Zegura SL. Mol Biol Evol. 2001 Jul; 18(7):1189-203.
Review The application of molecular genetic approaches to the study of human evolution. [Nat Genet. 2003]
Review The application of molecular genetic approaches to the study of human evolution.
Cavalli-Sforza LL, Feldman MW. Nat Genet. 2003 Mar; 33 Suppl:266-75.
Review Molecular genetics of speciation and human origins. [Proc Natl Acad Sci U S A. 1994]
Review Molecular genetics of speciation and human origins.
Ayala FJ, Escalante A, O'Huigin C, Klein J. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):6787-94.

See reviews... See all...

Cited by over 100 PubMed Central articles

Indian Siddis: African descendants with Indian admixture. [Am J Hum Genet. 2011]
Indian Siddis: African descendants with Indian admixture.
Shah AM, Tamang R, Moorjani P, Rani DS, Govindaraj P, Kulkarni G, Bhattacharya T, Mustak MS, Bhaskar LV, Reddy AG, et al. Am J Hum Genet. 2011 Jul 15; 89(1):154-61. Epub 2011 Jul 7.
A reduced representation approach to population genetic analyses and applications to human evolution. [Genome Res. 2011]
A reduced representation approach to population genetic analyses and applications to human evolution.
Luca F, Hudson RR, Witonsky DB, Di Rienzo A. Genome Res. 2011 Jul; 21(7):1087-98. Epub 2011 May 31.
A revised root for the human Y chromosomal phylogenetic tree: the origin of patrilineal diversity in Africa. [Am J Hum Genet. 2011]
A revised root for the human Y chromosomal phylogenetic tree: the origin of patrilineal diversity in Africa.
Cruciani F, Trombetta B, Massaia A, Destro-Bisol G, Sellitto D, Scozzari R. Am J Hum Genet. 2011 Jun 10; 88(6):814-8. Epub 2011 May 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Y chromosome sequence variation and the history of human populations.
Y chromosome sequence variation and the history of human populations.
Nat Genet. 2000 Nov ;26(3):358-61.

PubMed
Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from fo...
Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material.
Biotechniques. 1991 Apr ;10(4):506-13.

PubMed
[Dietary supplementation with bilberry extract prevents macular degeneration and...
[Dietary supplementation with bilberry extract prevents macular degeneration and cataracts in senesce-accelerated OXYS rats].
Adv Gerontol. 2005 ;16:76-9.

PubMed
Effect of diet on coronary-heart-disease mortality.
Effect of diet on coronary-heart-disease mortality.
Lancet. 1973 Aug 25 ;2(7826):438-9.

PubMed
Weight loss during oligofructose supplementation is associated with decreased gh...
Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults.
Am J Clin Nutr. 2009 Jun ;89(6):1751-9. Epub 2009 Apr 22 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Y chromosome sequence variation and the history of human populations.

Source

Abstract

Comment in

Publication Types, MeSH Terms, Secondary Source ID

Publication Types

MeSH Terms

Secondary Source ID

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information