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Nat Genet. 2000 Nov;26(3):253-4.
Y chromosome sequence variation and the history of human populations.
Underhill PA,
Shen P,
Lin AA,
Jin L,
Passarino G,
Yang WH,
Kauffman E,
Bonné-Tamir B,
Bertranpetit J,
Francalacci P,
Ibrahim M,
Jenkins T,
Kidd JR,
Mehdi SQ,
Seielstad MT,
Wells RS,
Piazza A,
Davis RW,
Feldman MW,
Cavalli-Sforza LL,
Oefner PJ.
Department of Genetics, Stanford University, Stanford, California, USA.under@stanford.edu
Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history. We used denaturing high-performance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.
PMID: 11062480 [PubMed - indexed for MEDLINE]