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    Nat Genet. 2000 Nov;26(3):267-8.

    Mater, a maternal effect gene required for early embryonic development in mice.

    Tong ZB, Gold L, Pfeifer KE, Dorward H, Lee E, Bondy CA, Dean J, Nelson LM.

    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland, USA.

    Maternal effect genes produce mRNA or proteins that accumulate in the egg during oogenesis. We show here that Mater, a mouse oocyte protein dependent on the maternal genome, is essential for embryonic development beyond the two-cell stage. Females lacking the maternal effect gene Mater are sterile. Null males are fertile.

    PMID: 11062459 [PubMed - indexed for MEDLINE]

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