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Br J Psychiatry. 2000 Nov;177:421-6.

Ten-year outcome: patients with schizoaffective disorders, schizophrenia, affective disorders and mood-incongruent psychotic symptoms.

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  • 1Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL, USA.

Abstract

BACKGROUND:

It is unclear whether outcome in schizoaffective disorders is more similar to schizophrenia or affective disorders.

AIMS:

To provide longitudinal data on clinical course and outcome in schizoaffective disorders versus schizophrenia and affective disorders, and determine whether mood-incongruent psychotic symptoms have negative prognostic implications.

METHOD:

A total of 210 patients with schizoaffective disorders, schizophrenia, bipolar manic disorders and depression were assessed at hospitalisation and then followed up four times over 10 years.

RESULTS:

At all four follow-ups, fewer patients with schizoaffective disorders than with schizophrenia showed uniformly poor outcome. Patients with mood-incongruent psychotic symptoms during index hospitalisation showed significantly poorer subsequent outcome (P < 0.05).

CONCLUSIONS:

Schizoaffective outcome was better than schizophrenic outcome and poorer than outcome for psychotic affective disorders. Mood-incongruent psychotic symptoms have negative prognostic implications. The results could fit a symptom dimension view of schizoaffective course.

PMID:
11059995
[PubMed - indexed for MEDLINE]
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