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Jpn J Clin Oncol. 2000 Aug;30(8):362-5.

Chronic neutrophilic leukemia with acute myeloblastic transformation.

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  • 1Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, Japan.

Abstract

We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and mu, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene.

PMID:
11059343
[PubMed - indexed for MEDLINE]
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