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Am J Psychiatry. 2000 Nov;157(11):1864-6.

Maintenance of brain monoamine oxidase B inhibition in smokers after overnight cigarette abstinence.

Author information

  • 1Brookhaven National Laboratory, Upton, NY 11973, USA. fowler@bnl.gov

Abstract

OBJECTIVE:

The authors' goal was to replicate a previous finding that smokers have lower brain monoamine oxidase B (MAO-B) levels than comparison nonsmoking subjects and to determine if levels recover after overnight cigarette abstinence.

METHOD:

Brain MAO-B levels were measured by means of positron emission tomography in six smokers who were scanned twice: 11.3 hours (baseline) and 10 minutes after smoking one cigarette.

RESULTS:

Average MAO-B levels in smokers in the present study were similar to those found in the previous study and averaged 39% (SD=17) lower than those found in a comparison group of nonsmokers. Brain MAO-B levels did not differ between baseline levels and 10 minutes after smoking.

CONCLUSIONS:

This study reinforces the need to investigate whether MAO-B inhibition may account for some of the behavioral and epidemiological features of smoking.

PMID:
11058487
[PubMed - indexed for MEDLINE]
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