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Jpn J Infect Dis. 2000 Aug;53(4):156-61.

Jackfruit lectin: properties of mitogenicity and the inhibition of herpesvirus infection.

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  • 1Department of Biotechnology, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.


Jackfruit lectin (JFL) from Artocarpus heterophyllus has been found to exhibit inhibitory activity in vitro with a cytopathic effect towards herpes simplex virus type 2 (HSV-2), varicella-zoster virus (VZV), and cytomegalovirus (CMV). The 50% inhibitory dose values from plaque reduction assay (inactivation) were 2.5, 5, and 10 Eg/ml of JFL for HSV-2, VZV, and CMV, respectively. Lymphocyte proliferation was significantly increased in the presence of the JFL in the concentration range of 2.5 to 50 Eg/ml, but was reduced at 500 Eg/ml. It was found that CD16(+)/CD56(+) cells (natural killer cells) were induced among the primary lymphocyte subpopulations. The activity of natural killer (NK) cells was not affected by JFL in the concentration range of 5 to 500 Eg/ml. These data suggest that JFL is mitogenic for NK lymphocyte (CD16(+)/CD56(+)) and also active against HSV-2, VZV, and CMV.

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