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    Eur J Cancer. 2000 Sep;36 Suppl 4:S87-8.

    Faslodex (ICI 182780). an oestrogen receptor downregulator.

    Howell A.

    CRC Department of Medical Oncology, Christie Hospital NHS Trust, M20 4BX, Manchester, UK. maria.parker@christie-tr.nwest.nhs.uk

    Anti-oestrogen therapy, tamoxifen in particular, has revolutionised the treatment of breast cancer. However, the partial agonist activity of tamoxifen is associated with an increased risk of endometrial cancer and the acquisition by patients of tamoxifen-resistance. In an attempt overcome these negative aspects of tamoxifen therapy, 'pure' anti-oestrogens have been developed and are currently being investigated for the treatment of breast cancer.

    PMID: 11056334 [PubMed - indexed for MEDLINE]

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    Cited by 4 PubMed Central articles

    Patient drug information

    • Estrogen (Cenestin®, Enjuvia®, Estrace®, ...)

      Estrogen is used to treat hot flushes ('hot flashes'; sudden strong feelings of heat and sweating) in women who are experiencing menopause ('change of life', the end of monthly menstrual periods). Some brands of estrogen...

    • Tamoxifen (Nolvadex®)

      Your doctor has prescribed tamoxifen for you. Tamoxifen comes as a tablet to take by mouth.

    • Source: AHFS Consumer Medication Information

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