Trends Genet. 2000 Oct;16(10):469-73.

Internal ribosome initiation of translation and the control of cell death.

Source

Solange Gauthier Karsh Molecular Genetics Laboratory, Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, ON, K1H 8L1, Ottawa, Canada. martin@mgcheo.med.uottawa.ca

Abstract

The majority of cellular stresses lead to the inhibition of cap-dependent translation. Some mRNAs, however, are translated by a cap-independent mechanism, mediated by ribosome binding to internal ribosome entry site (IRES) elements located in the 5' untranslated region. Interestingly, IRES elements are found in the mRNAs of several survival factors, oncogenes and proteins crucially involved in the control of apoptosis. These mRNAs are translated under a variety of stress conditions, including hypoxia, serum deprivation, irradiation and apoptosis. Thus, IRES-mediated translational control might have evolved to regulate cellular responses in acute but transient stress conditions that would otherwise lead to cell death.

PMID:: 11050335; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1. [J Biol Chem. 2003]
Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1.
Nevins TA, Harder ZM, Korneluk RG, Holcík M. J Biol Chem. 2003 Feb 7; 278(6):3572-9. Epub 2002 Nov 27.
Monocistronic mRNAs containing defective hepatitis C virus-like picornavirus internal ribosome entry site elements in their 5' untranslated regions are efficiently translated in cells by a cap-dependent mechanism. [RNA. 2008]
Monocistronic mRNAs containing defective hepatitis C virus-like picornavirus internal ribosome entry site elements in their 5' untranslated regions are efficiently translated in cells by a cap-dependent mechanism.
Belsham GJ, Nielsen I, Normann P, Royall E, Roberts LO. RNA. 2008 Aug; 14(8):1671-80. Epub 2008 Jun 20.
Eukaryotic initiation factor 4G-poly(A) binding protein interaction is required for poly(A) tail-mediated stimulation of picornavirus internal ribosome entry segment-driven translation but not for X-mediated stimulation of hepatitis C virus translation. [Mol Cell Biol. 2001]
Eukaryotic initiation factor 4G-poly(A) binding protein interaction is required for poly(A) tail-mediated stimulation of picornavirus internal ribosome entry segment-driven translation but not for X-mediated stimulation of hepatitis C virus translation.
Michel YM, Borman AM, Paulous S, Kean KM. Mol Cell Biol. 2001 Jul; 21(13):4097-109.
Review Re-programming of translation following cell stress allows IRES-mediated translation to predominate. [Biol Cell. 2008]
Review Re-programming of translation following cell stress allows IRES-mediated translation to predominate.
Spriggs KA, Stoneley M, Bushell M, Willis AE. Biol Cell. 2008 Jan; 100(1):27-38.
Review Cap-independent regulation of gene expression in apoptosis. [Mol Biosyst. 2007]
Review Cap-independent regulation of gene expression in apoptosis.
Graber TE, Holcik M. Mol Biosyst. 2007 Dec; 3(12):825-34. Epub 2007 Sep 18.

See reviews... See all...

Cited by 44 PubMed Central articles

Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism. [PLoS One. 2011]
Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism.
Contreras V, Friday AJ, Morrison JK, Hao E, Keiper BD. PLoS One. 2011; 6(9):e24444. Epub 2011 Sep 1.
Protein multifunctionality: principles and mechanisms. [Transl Oncogenomics. 2008]
Protein multifunctionality: principles and mechanisms.
Zaretsky JZ, Wreschner DH. Transl Oncogenomics. 2008 May 15; 3:99-136. Epub 2008 May 15.
Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138. [J Virol. 2010]
Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138.
Grainger L, Cicchini L, Rak M, Petrucelli A, Fitzgerald KD, Semler BL, Goodrum F. J Virol. 2010 Sep; 84(18):9472-86. Epub 2010 Jun 30.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Internal ribosome initiation of translation and the control of cell death.
Internal ribosome initiation of translation and the control of cell death.
Trends Genet. 2000 Oct ;16(10):469-73.

PubMed
Control and prevention of tuberculosis in the United Kingdom: code of practice 2...
Control and prevention of tuberculosis in the United Kingdom: code of practice 2000. Joint Tuberculosis Committee of the British Thoracic Society.
Thorax. 2000 Nov ;55(11):887-901.

PubMed
A single amino acid substitution (F363I) converts the regiochemistry of the spea...
A single amino acid substitution (F363I) converts the regiochemistry of the spearmint (-)-limonene hydroxylase from a C6- to a C3-hydroxylase.
Proc Natl Acad Sci U S A. 2000 Oct 24 ;97(22):11948-53.

PubMed
Plasticity in the neural coding of auditory space in the mammalian brain.
Plasticity in the neural coding of auditory space in the mammalian brain.
Proc Natl Acad Sci U S A. 2000 Oct 24 ;97(22):11821-8.

PubMed
Cooperative subunit interactions within the oligomeric envelope glycoprotein of ...
Cooperative subunit interactions within the oligomeric envelope glycoprotein of HIV-1: functional complementation of specific defects in gp120 and gp41.
Proc Natl Acad Sci U S A. 2000 Nov 7 ;97(23):12794-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Internal ribosome initiation of translation and the control of cell death.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 44 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information