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Trends Genet. 2000 Oct;16(10):461-8.

It takes two transposons to tango: transposable-element-mediated chromosomal rearrangements.

Author information

  • Molecular Genetics and Evolution Group, Research School of Biological Sciences, Australian National University, ACT 2601, Canberra, Australia. gray@rsbs.anu.edu.au

Abstract

Transposable elements (TEs) promote various chromosomal rearrangements more efficiently, and often more specifically, than other cellular processes(1-3). One explanation of such events is homologous recombination between multiple copies of a TE present in a genome. Although this does occur, strong evidence from a number of TE systems in bacteria, plants and animals suggests that another mechanism - alternative transposition - induces a large proportion of TE-associated chromosomal rearrangements. This paper reviews evidence for alternative transposition from a number of unrelated but structurally similar TEs. The similarities between alternative transposition and V(D)J recombination are also discussed, as is the use of alternative transposition as a genetic tool.

PMID:
11050333
[PubMed - indexed for MEDLINE]
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