Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Genet. 2000 Oct;16(10):442-9.

Genes that fight infection: what the Drosophila genome says about animal immunity.

Author information

  • 1Centre de Génétique Moléculaire, CNRS, 91198, Gif-sur-Yvette, France.

Abstract

From deciphering the principles of heredity to identifying the genes that control development, the fruit fly Drosophila melanogaster is being used to deconstruct an increasing number of biological processes. Genetic studies of Drosophila responses to microbial infection have identified regulators of innate immunity that are functionally conserved in mammals. These recent findings highlight the ancient origins of animal immune responses and demonstrate the potential of Drosophila for dissecting host-pathogen interactions. The sequencing of the Drosophila genome both enhances genetic approaches and provides new clues for the identification of key components of innate immunity. This article summarizes how information gained from genomic analysis contributes to our understanding of how animals cope with infectious disease.

PMID:
11050330
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk