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Trends Genet. 2000 Oct;16(10):423-5.

Analysing uncharted transcriptomes with SAGE.

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  • 1Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, 1650 Orleans St., Baltimore MD 21231, USA. velculescu@jhmi.edu


Methods of comprehensive gene expression analysis have traditionally been limited to analysing bulk tissue or millions of cells. New modifications of serial analysis of gene expression (SAGE) have now permitted the analysis of gene expression in cell subpopulations or microanatomic structures, providing access to unexplored transcriptomes of normal and disease biology.

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