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Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11714-21.

Cellular studies of auditory hair cell regeneration in birds.

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  • 1Virginia Merrill Bloedel Hearing Research Center, University of Washington School of Medicine, Seattle, WA 98195-7923, USA.


A decade ago it was discovered that mature birds are able to regenerate hair cells, the receptors for auditory perception. This surprising finding generated hope in the field of auditory neuroscience that new hair cells someday may be coaxed to form in another class of warm-blooded vertebrates, mammals. We have made considerable progress toward understanding some cellular and molecular events that lead to hair cell regeneration in birds. This review discusses our current understanding of avian hair cell regeneration, with some comparisons to other vertebrate classes and other regenerative systems.

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