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Blood. 2000 Nov 1;96(9):3282-5.

Adhesion to 90K (Mac-2 BP) as a mechanism for lymphoma drug resistance in vivo.

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  • 1Department of Oncology and Neurosciences, University G. D'Annunzio Medical School, Chieti, Italy.

Abstract

A cell-adhesive protein of the human serum, 90K binds galactin-3, beta1-integrins, collagens, and fibronectin, and it is of importance in cell-cell and cell-extracellular matrix adhesion. Serum 90K levels in 137 patients with lymphoma were measured by enzyme-linked immunosorbent assay. Compared with healthy controls, pretreatment serum 90K levels in patients with lymphoma were elevated (P <.001). Of 97 patients who showed objective response to treatment, 20 (21%) had pretreatment 90K levels above the normal cutoff compared with 17 (53%) of 32 patients who did not respond (P =.002). When used as a plastic-immobilized substrate, 90K caused a significant reduction in chemotherapy-induced apoptosis of Jurkat T lymphoma cells. This finding could explain the lack of response in lymphoma patients with high 90K serum levels.

PMID:
11050016
[PubMed - indexed for MEDLINE]
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