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Clin Infect Dis. 2000 Oct;31(4):1110-3.

Short-course of oral miltefosine for treatment of visceral leishmaniasis.

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  • 1The Kala-Azar Medical Research Center, Banaras Hindu University Institute of Medical Sciences, Varanasi, India. shyams@nde.vsnl.net.in


A total of 54 Indian patients with visceral leishmaniasis were treated with oral miltefosine, 50 mg given twice daily, for 14 days (18 patients; group A), 21 days (18; group B), or 28 days (18; group C). Cure was achieved in 89% of group A, 100% of group B, and 100% of group C. Adverse reactions were self-limited and primarily mild. The 21-day miltefosine regimen combines high-level efficacy, convenient dosing, and a relatively short duration.

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