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    Am J Dermatopathol. 2000 Oct;22(5):447-52.

    Association of human papillomavirus type 6 with a verruciform xanthoma.

    Khaskhely NM, Uezato H, Kamiyama T, Maruno M, Kariya KI, Oshiro M, Nonaka S.

    Source

    Department of Dermatology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan. khaskhelis@hotmail.com

    Abstract

    We report a case of verruciform xanthoma (VX) associated with human papillomavirus (HPV) in a 67-year-old male. The patient had a pale-reddish, granular and verrucous tumor on the right side of his scrotum for four years. Histopathologic examination showed typical features of VX. HPV was detected by immunohistochemistry, electron microscopy, and PCR examinations. Ultrastructural examination revealed virus-like particles of 40-50 nm in the nucleus of the upper epidermal keratinocytes. HPV type 6a DNA was detected in lesional tissue by polymerase chain reaction and sequence analysis. To the best of our knowledge, this is the first case report of VX associated with HPV.

    PMID:
    11048983
    [PubMed - indexed for MEDLINE]

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