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Nature. 2000 Oct 12;407(6805):770-6.

The biochemistry of apoptosis.

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  • Cold Spring Harbor Laboratory, New York 11724, USA. hengartn@cshl.org

Abstract

Apoptosis--the regulated destruction of a cell--is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating its self-destruction programme. Once the decision is taken, proper execution of the apoptotic programme requires the coordinated activation and execution of multiple subprogrammes. Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death.

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PMID:
11048727
[PubMed - indexed for MEDLINE]
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