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Trends Microbiol. 2000 Oct;8(10):452-6.

The Toll receptor family and microbial recognition.

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  • 1Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. ruslan@yale.edu


The survival of multicellular organisms is dependent on their ability to recognize invading microbial pathogens and to induce a variety of defense reactions. Recent evidence suggests that an evolutionarily ancient family of Toll-like receptors plays a crucial role in the detection of microbial infection and the induction of immune and inflammatory responses.

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