Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Endocrinol Metab. 2000 Nov;11(9):375-8.

Life and death of the pancreatic beta cells.

Author information

  • 1Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA. susan.bonner-weir@joslin.harvard.edu

Abstract

Pancreatic beta cells are responsible for maintaining the body's glucose levels within a very narrow range; their population is dynamic, with compensatory changes to maintain euglycemia. Throughout the lifetime of a mammal, low levels of beta-cell replication and apoptosis are balanced and result in a slowly increasing mass of beta cells. The emphasis in this review is on recent insights on the natural history of the beta cell in a normal pancreas: sources of renewal, survival and changes in differentiation.

PMID:
11042468
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk