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Curr Opin Struct Biol. 2000 Oct;10(5):558-63.

High-throughput protein crystallization.

Author information

  • The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. stevens@scripps.edu

Abstract

The combinatorial chemistry industry has made major advances in the handling and mixing of small volumes, and in the development of robust liquid-handling systems. In addition, developments have been made in the area of material handling for the high-throughput drug screening and combinatorial chemistry fields. Lastly, improvements in beamline optics at synchrotron sources have enabled the use of flash-frozen micron-sized (10-50 microm) crystals. The combination of these and other recent advances will make high-throughput protein crystallography possible. Further advances in high-throughput methods of protein crystallography will require application of the above developments and the accumulation of success/failure data in a more systematic manner. Major changes in crystallography technology will emerge based on the data collected by first-generation high-throughput systems.

PMID:
11042454
[PubMed - indexed for MEDLINE]
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