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    Brain Dev. 2000 Sep;22(6):373-7.

    Combined therapy with hypothermia and anticytokine agents in influenza A encephalopathy.

    Munakata M, Kato R, Yokoyama H, Haginoya K, Tanaka Y, Kayaba J, Kato T, Takayanagi R, Endo H, Hasegawa R, Ejima Y, Hoshi K, Iinuma K.

    Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan. muna@ped.med.tohoku.ac.jp

    Two children with influenza A-related encephalopathy were treated with a combination of mild hypothermia (deep body temperature of the forehead: 35 degrees C) and anticytokine agents (high-dose methylprednisolone and ulinastatin), while receiving amantadine. One of the cases exhibited acute necrotizing encephalopathy on computed tomography (CT). Although no severe complications occurred, correctable hypokalemia and hyperglycemia occurred in both cases. Both patients recovered without any neurological sequelae. Our therapeutic protocol appears to be effective for managing influenza A-related encephalopathy.

    PMID: 11042419 [PubMed - indexed for MEDLINE]

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    • Amantadine (Symmetrel®, Symmetrel® Syrup)

      Amantadine is used to treat Parkinson's disease and conditions similar to those of Parkinson's disease. It also is used to prevent and treat respiratory infections caused by influenza A virus.

    • Source: AHFS Consumer Medication Information

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