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1: Tissue Antigens. 2000 Sep;56(3):272-5.Click here to read Links

Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen.

Watanabe Y, Shimada E, Fujiwara K, Niihara H, Shimano K, Mitsunaga S, Tadokoro K, Juji T.

Transfusion Information Department, Japanese Red Cross Central Blood Center, Tokyo. watanabe@cbc.jrc.or.jp

A new allele of the human neutrophil antigen (HNA) system (tentatively called NA2M) was discovered and its nucleotide sequence was determined. NA2M differs in a single nucleotide (193G-->A) from FCGR3B*2(NA2), resulting in an amino acid change (54Glu-->Lys). The frequency of the NA2M gene in the Japanese population was estimated to be 0.008. Granulocytes of individuals possessing NA2M reacted with HNA-1b(NA2)-specific monoclonal antibody (TAG2) in the GIFT assay.

PMID: 11034564 [PubMed - indexed for MEDLINE]