Source
Department of Dermatology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Abstract
OBJECTIVE:
To compare the efficacy and safety of valacyclovir hydrochloride and famciclovir for the treatment of herpes zoster.
DESIGN:
A double-blind, randomized, controlled, multicenter clinical trial in which patients received 7 days of treatment and were followed up for 24 weeks.
SETTINGS:
Patients reported directly to specialist centers or were referred from primary care centers.
PATIENTS:
There were 597 otherwise healthy immunocompetent outpatients, aged 50 years and older, who presented within 72 hours of onset of zoster rash.
INTERVENTIONS:
Treatment with valacyclovir hydrochloride (1 g 3 times daily) or famciclovir (500 mg 3 times daily) for 7 days.
MAIN OUTCOME MEASURES:
Resolution of zoster-associated pain and postherpetic neuralgia, rash healing, and treatment safety.
RESULTS:
Intent-to-treat analysis did not detect statistically significant differences for valacyclovir vs famciclovir on resolution of zoster-associated pain (hazard ratio, 1. 02; 95% confidence interval, 0.84-1.23; P =.84). Furthermore, no differences were evident between treatments on rash healing rates and on a range of analyses of postherpetic neuralgia. Safety profiles for valacyclovir and famciclovir were similar, with headache and nausea being the more common adverse events.
CONCLUSIONS:
Valacyclovir treatment is comparable to famciclovir treatment in speeding the resolution of zoster-associated pain and postherpetic neuralgia. Current wholesale prices indicate that valacyclovir is the more cost-effective treatment for herpes zoster ($83.90 vs $140.70 per course).