Cell Mol Life Sci. 2000 Aug;57(8-9):1184-92.

Regulation of gene expression by transcription factor acetylation.

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Wellcome/CRC Institute and Department of Pathology, University of Cambridge, United Kingdom. ab149@mole.bio.cam.ac.uk

Abstract

In the nucleus, DNA is tightly packaged into higher-order structures, generating an environment that is highly repressive towards DNA processes such as gene transcription. Acetylation of lysine residues within proteins has recently emerged as a major mechanism used by the cell to overcome this repression. Acetylation of non-histone proteins, including transcription factors, as well as histones, appears to be involved in this process. Like phosphorylation, acetylation is a dynamic process that can regulate protein-DNA and protein-protein interactions. Moreover, a conserved domain, the bromodomain, has been implicated in the binding of acetylated peptides, suggesting a role for acetylation in intracellular signalling.

PMID:: 11028911; [PubMed - indexed for MEDLINE]

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