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Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11427-32.

Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila.

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  • 1Institut de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Unité Propre de Recherche, Strasbourg, France. M.Lagueux@ibmc.u-strasbg.fr

Abstract

We show that Drosophila expresses four genes encoding proteins with significant similarities with the thiolester-containing proteins of the complement C3/alpha(2)-macroglobulin superfamily. The genes are transcribed at a low level during all stages of development, and their expression is markedly up-regulated after an immune challenge. For one of these genes, which is predominantly expressed in the larval fat body, we observe a constitutive expression in gain-of-function mutants of the Janus kinase (JAK) hop and a reduced inducibility in loss-of-function hop mutants. We also observe a constitutive expression in gain-of-function Toll mutants. We discuss the possible roles of these novel complement-like proteins in the Drosophila host defense.

PMID:
11027343
[PubMed - indexed for MEDLINE]
PMCID:
PMC17216
Free PMC Article

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