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    Mech Dev. 2000 Oct;97(1-2):161-5.

    Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace.

    Adamska M, Léger S, Brand M, Hadrys T, Braun T, Bober E.

    Source

    Department of Molecular and Cellular Biology, Technical University, Braunschweig, Spielmannstrasse 7, D-38106, Braunschweig, Germany.

    Abstract

    An orthologue of the mouse homeobox gene Nkx5-1 was cloned and characterized in the zebrafish. As in the mouse and chick, the zebrafish Nkx5-1 gene is expressed in the ear placode and vesicle and in cells forming the vestibulo-acoustic ganglion. In addition, a novel expression domain, the lateral line, appears in the zebrafish, supporting a common precursor hypothesis for these two organs. In the FGF8 zebrafish mutant ace, expression of Nkx5-1 in the otic structures is diminished. The most significant reduction of zfNkx5-1 expression was observed in cells of the vestibulo-acoustic ganglion.

    PMID:
    11025218
    [PubMed - indexed for MEDLINE]

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