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Clin Infect Dis. 2000 Sep;31(3):826-9.

Treatment of latent tuberculosis infection in patients aged > or =35 years.

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  • 1Department of Medicine, Division of Infectious Diseases, SUNY Upstate Medical University, Syracuse, NY 13210, USA.


Treating patients aged > or =35 years for tuberculosis infection has been controversial because of the hepatotoxic effects of isoniazid. A 2-year retrospective cohort study of outpatient medical records determined the completion rate in this age group and identified risk factors associated with isoniazid-associated hepatotoxicity. Isoniazid preventative therapy was well tolerated. However, toxicity occurred in women receiving concomitant medications and men who used alcohol.

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