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Nat Genet. 2000 Oct;26(2):163-75.

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.

Author information

  • 1Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois, USA.

Erratum in

  • Nat Genet 2000 Dec;26(4):502.

Abstract

Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.

Comment in

  • Guilt by association. [Nat Genet. 2000]
PMID:
11017071
[PubMed - indexed for MEDLINE]
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