Neutral taxoids from Taxus cuspidata as modulators of multidrug-resistant tumor cells

K Kosugi; J Sakai; S Zhang; Y Watanabe; H Sasaki; T Suzuki; H Hagiwara; N Hirata; K Hirose; M Ando; A Tomida; T Tsuruo

doi:10.1016/s0031-9422(00)00108-4

Neutral taxoids from Taxus cuspidata as modulators of multidrug-resistant tumor cells

Phytochemistry. 2000 Aug;54(8):839-45. doi: 10.1016/s0031-9422(00)00108-4.

Authors

K Kosugi¹, J Sakai, S Zhang, Y Watanabe, H Sasaki, T Suzuki, H Hagiwara, N Hirata, K Hirose, M Ando, A Tomida, T Tsuruo

Affiliation

¹ Graduate School of Science and Technology, Niigata University, Japan.

PMID: 11014276
DOI: 10.1016/s0031-9422(00)00108-4

Abstract

Two taxoids, taxinine NN-7 (1) and 3,11-cyclotaxinine NN-2 (2), were isolated from the neutral fraction of the EtOAc extract of a mixture of needles and young stems of Taxus cuspidata. The structures were determined by spectroscopic analysis. Both compounds showed some activity as modulators of multidrug-resistant tumor cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Drug Resistance, Multiple*
Drug Resistance, Neoplasm*
Paclitaxel / analogs & derivatives
Paclitaxel / chemistry
Paclitaxel / isolation & purification*
Paclitaxel / pharmacology
Taxoids*
Trees / chemistry*
Tumor Cells, Cultured

Substances

3,11-cyclotaxinine NN-2
Diterpenes
Taxoids
taxinine NN-7
Paclitaxel