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Am J Psychiatry. 2000 Oct;157(10):1689-91.

Thyroid hormone levels and recurrence of major depression.

Author information

  • 1Mood Disorders Program and Department of Psychiatry, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. joffe@fhs.csu.mcmaster.ca

Abstract

OBJECTIVE:

The relationship between basal thyroid hormone levels and acute antidepressant response has been studied, but any relationship between basal thyroid hormone levels and long-term course of depressive illness has not been evaluated.

METHOD:

The authors used a Cox regression survival analysis to evaluate the relationship between life course of depressive illness and basal levels of thyroid hormones (triiodothyronine [T(3)], thyroxine [T(4)], and thyrotropin) in 75 outpatients with unipolar major depressive disorder.

RESULTS:

Time to recurrence of major depression was inversely related to T(3) levels but not to T(4) levels.

CONCLUSIONS:

These data may be of clinical interest in view of the fact that T(3) is used to augment antidepressant response.

PMID:
11007728
[PubMed - indexed for MEDLINE]
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