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J Mal Vasc. 2000 Jun;25(3):156-65.

[Interest in variations in soluble ICAM-1 plasma levels. From physiology to clinical applications].

[Article in French]

Author information

  • 1Laboratoire Universitaire d'Hématologie, Université Victor Ségalen, Bordeaux, France.


Intracellular adhesion molecule 1 (ICAM-1) is an adhesion-related molecule belonging to the immunoglobulin superfamily. This molecule is found on the cell membrane of endothelial cells. When activated ICAM-1 allows stable leukocyte adhesion to the endothelial surface. ICAM-1 is found not only in the membrane form but also circulating in serum. ICAM-1 (extracellular part of ICAM-1). This enables ICAM-1s to bind leukocyte integrin receptors such as LFA-1 (CDI1a/CD18) and Mac-1 (CDI1b/CD18) and therefore provide adaptive changes in the adhesion process between circulating cells and the endothelium.

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