bis-Quinolinium cyclophanes: 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca(2+)-activated K(+) channel

J Med Chem. 2000 Sep 21;43(19):3478-81. doi: 10.1021/jm000904v.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apamin / pharmacology*
  • Calcium / physiology*
  • Cells, Cultured
  • Neurons / cytology
  • Neurons / drug effects
  • Neurons / physiology
  • Potassium Channel Blockers*
  • Potassium Channels*
  • Potassium Channels, Calcium-Activated*
  • Quinolinium Compounds / chemical synthesis*
  • Quinolinium Compounds / chemistry
  • Quinolinium Compounds / pharmacology
  • Rats
  • Small-Conductance Calcium-Activated Potassium Channels
  • Structure-Activity Relationship

Substances

  • 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane
  • Potassium Channel Blockers
  • Potassium Channels
  • Potassium Channels, Calcium-Activated
  • Quinolinium Compounds
  • Small-Conductance Calcium-Activated Potassium Channels
  • Apamin
  • Calcium