Abstract
The Drosophila JAK-STAT pathway and its ligand Unpaired are required for a wide range of developmental processes. Recent results have identified Unpaired as an activator of sex-lethal and revealed a new role for the JAK-STAT pathway in sex determination.
MeSH terms
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Animals
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DNA-Binding Proteins / metabolism
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Drosophila Proteins*
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Drosophila melanogaster / genetics*
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Drosophila melanogaster / physiology
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Female
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Gene Expression Regulation
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Glycoproteins / genetics*
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Glycoproteins / metabolism
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Insect Hormones / genetics*
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Insect Hormones / metabolism
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Male
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Protein-Tyrosine Kinases / metabolism*
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RNA-Binding Proteins / genetics*
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RNA-Binding Proteins / metabolism
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STAT1 Transcription Factor
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Sex Chromosomes / genetics
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Sex Chromosomes / metabolism
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Sex Determination Processes*
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Signal Transduction
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Trans-Activators / metabolism
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Transcription Factors*
Substances
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DNA-Binding Proteins
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Drosophila Proteins
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Glycoproteins
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Insect Hormones
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RNA-Binding Proteins
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STAT1 Transcription Factor
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Sxl protein, Drosophila
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Trans-Activators
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Transcription Factors
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upd1 protein, Drosophila
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Protein-Tyrosine Kinases