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Curr Biol. 2000 Sep 7;10(17):R624-6.

Tumor suppressors: linking cell polarity and growth control.

Author information

  • Institut für Genetik, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. wodarz@uni-duesseldorf.de

Abstract

The Drosophila tumor suppressor genes scribble, discs large and lethal giant larvae appear to act in a common pathway. Mutations in any of these genes lead to loss of apical-basal cell polarity and overproliferation of epithelia, revealing a close connection between cytoarchitecture and growth control.

PMID:
10996086
[PubMed - indexed for MEDLINE]
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