J Bacteriol. 1975 Sep;123(3):1254-64.

Deletions fusing the hisG and hisD genes in Salmonella typhimurium.

Abstract

Frameshift mutation hisD497 occurs in the operator-proximal portion of the Salmonella typhimurium gene coding for the dimeric protein, L-histidinol dehydrogenase (HDH). Rare revertants of hisD497 are deletions fusing the hisD gene to the adjacent preceding structural gene, hisG (adenosine 5'-triphosphate-PR transferase). HDH purified from one revertant, hisGD4908, contains subunits of approximately normal molecular weight but with no clearly demonstrable unique amino-terminal sequence. We propose that a combined inactive G-D polypeptide is synthesized and then cleaved at a number of closely juxtaposed sites by endoproteolytic activity. At least some of the resulting fragments then participate in formation of active HDH dimers.

PMID:: 1099075; [PubMed - indexed for MEDLINE]
PMCID:: PMC235849

Free PMC Article

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

(L)-HISTIDINE - HSDB

Supplemental Content

Save items

Related citations in PubMed

The pi-histidine factor of Salmonella typhimurium: a demonstration that pi-histidine factor integrates into the chromosome. [J Bacteriol. 1972]
The pi-histidine factor of Salmonella typhimurium: a demonstration that pi-histidine factor integrates into the chromosome.
Levinthal M, Yeh J. J Bacteriol. 1972 Mar; 109(3):993-1000.
Physiological studies of salmonella histidine operator-promoter mutants. [Genetics. 1974]
Physiological studies of salmonella histidine operator-promoter mutants.
Ely B. Genetics. 1974 Oct; 78(2):593-606.
Regulation of histidine operon does not require hisG enzyme. [Proc Natl Acad Sci U S A. 1975]
Regulation of histidine operon does not require hisG enzyme.
Scott JF, Roth JR, Artz SW. Proc Natl Acad Sci U S A. 1975 Dec; 72(12):5021-5.
Review Regulation of the histidine operon: translation-controlled transcription termination (a mechanism common to several biosynthetic operons). [Curr Top Cell Regul. 1981]
Review Regulation of the histidine operon: translation-controlled transcription termination (a mechanism common to several biosynthetic operons).
Blasi F, Bruni CB. Curr Top Cell Regul. 1981; 19:1-45.
Review Classification and mapping of spontaneous and induced mutations in the histidine operon of Salmonella. [Adv Genet. 1971]
Review Classification and mapping of spontaneous and induced mutations in the histidine operon of Salmonella.
Hartman PE, Hartman Z, Stahl RC. Adv Genet. 1971; 16:1-34.

See reviews... See all...

Cited by 5 PubMed Central articles

Possible regulation of the Salmonella typhimurium histidine operon by adenosine triphosphate phosphoribosyltransferase: large metabolic effects. [J Bacteriol. 1980]
Possible regulation of the Salmonella typhimurium histidine operon by adenosine triphosphate phosphoribosyltransferase: large metabolic effects.
Goitein RK, Parsons SM. J Bacteriol. 1980 Oct; 144(1):337-45.
The leader mRNA of the histidine attenuator region resembles tRNAHis: possible general regulatory implications. [Proc Natl Acad Sci U S A. 1983]
The leader mRNA of the histidine attenuator region resembles tRNAHis: possible general regulatory implications.
Ames BN, Tsang TH, Buck M, Christman MF. Proc Natl Acad Sci U S A. 1983 Sep; 80(17):5240-2.
Purification and in vitro complementation of mutant histidinol dehydrogenases. [J Bacteriol. 1987]
Purification and in vitro complementation of mutant histidinol dehydrogenases.
Lee SY, Grubmeyer CT. J Bacteriol. 1987 Sep; 169(9):3938-44.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Deletions fusing the hisG and hisD genes in Salmonella typhimurium.
Deletions fusing the hisG and hisD genes in Salmonella typhimurium.
J Bacteriol. 1975 Sep ;123(3):1254-64.

PubMed
The impact of music therapy on language functioning in dementia.
The impact of music therapy on language functioning in dementia.
J Music Ther. 2000 Fall ;37(3):183-95.

PubMed
Histopathology of celiac disease.
Histopathology of celiac disease.
Biomed Pharmacother. 2000 Aug ;54(7):368-72.

PubMed
Dietary-fiber hypothesis of the etiology of diabetes mellitus.
Dietary-fiber hypothesis of the etiology of diabetes mellitus.
Diabetes. 1975 Aug ;24(8):762-5.

PubMed
Transfemoral socket design and suspension options.
Transfemoral socket design and suspension options.
Phys Med Rehabil Clin N Am. 2000 Aug ;11(3):569-83, vi.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Deletions fusing the hisG and hisD genes in Salmonella typhimurium.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 5 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information