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1: J Bacteriol. 2000 Oct;182(19):5611-4.Click here to read Click here to read Links

Bacillus subtilis ccpA gene mutants specifically defective in activation of acetoin biosynthesis.

Turinsky AJ, Moir-Blais TR, Grundy FJ, Henkin TM.

Department of Biochemistry and Molecular Biology, Albany Medical College, Albany, New York 12208, USA.

A large number of carbon source utilization pathways are repressed in Bacillus subtilis by the global regulator CcpA, which also acts as an activator of carbon excretion pathways during growth in media containing glucose. In this study, CcpA mutants defective in transcriptional activation of the alsSD operon, which is involved in acetoin biosynthesis, were identified. These mutants retained normal glucose repression of amyE, encoding alpha-amylase, and acsA, encoding acetyl-coenzyme A synthetase, and normal activation of ackA, which is involved in acetate excretion; in these ccpA mutants the CcpA functions of activation of the acetate and acetoin excretion pathways appear to be separated.

PMID: 10986270 [PubMed - indexed for MEDLINE]

PMCID: PMC111010