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Genome Res. 2000 Sep;10(9):1304-6.

Active conservation of noncoding sequences revealed by three-way species comparisons.

Author information

  • 1Center for Bioinformatics and Computational Genomics, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

Abstract

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.

PMID:
10984448
[PubMed - indexed for MEDLINE]
PMCID:
PMC310906
Free PMC Article

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