Abstract
Insulin-like growth factor I (IGF-I) stimulates osteoblastic cells in culture to proliferate and to synthesize bone matrix proteins. However, local IGF-I action is modulated by a family of IGF-binding proteins (IGFBPs) that, in turn, are modified by specific IGFBP proteases. All these components of the IGF-I regulatory system are present and operative in bone cells in vitro.
MeSH terms
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Animals
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Bone and Bones / metabolism*
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Cell Division
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Cells, Cultured
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Humans
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Insulin-Like Growth Factor Binding Protein 4 / metabolism
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Insulin-Like Growth Factor Binding Protein 5 / metabolism
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Insulin-Like Growth Factor Binding Proteins / metabolism
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Insulin-Like Growth Factor I / biosynthesis*
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Insulin-Like Growth Factor I / physiology
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Metalloendopeptidases / metabolism
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Models, Biological
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Osteoblasts / metabolism
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Tumor Cells, Cultured
Substances
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Insulin-Like Growth Factor Binding Protein 4
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Insulin-Like Growth Factor Binding Protein 5
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Insulin-Like Growth Factor Binding Proteins
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Insulin-Like Growth Factor I
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Metalloendopeptidases