In vitro studies of insulin-like growth factor I and bone

Growth Horm IGF Res. 2000 Apr:10 Suppl B:S107-10. doi: 10.1016/s1096-6374(00)80020-9.

Abstract

Insulin-like growth factor I (IGF-I) stimulates osteoblastic cells in culture to proliferate and to synthesize bone matrix proteins. However, local IGF-I action is modulated by a family of IGF-binding proteins (IGFBPs) that, in turn, are modified by specific IGFBP proteases. All these components of the IGF-I regulatory system are present and operative in bone cells in vitro.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone and Bones / metabolism*
  • Cell Division
  • Cells, Cultured
  • Humans
  • Insulin-Like Growth Factor Binding Protein 4 / metabolism
  • Insulin-Like Growth Factor Binding Protein 5 / metabolism
  • Insulin-Like Growth Factor Binding Proteins / metabolism
  • Insulin-Like Growth Factor I / biosynthesis*
  • Insulin-Like Growth Factor I / physiology
  • Metalloendopeptidases / metabolism
  • Models, Biological
  • Osteoblasts / metabolism
  • Tumor Cells, Cultured

Substances

  • Insulin-Like Growth Factor Binding Protein 4
  • Insulin-Like Growth Factor Binding Protein 5
  • Insulin-Like Growth Factor Binding Proteins
  • Insulin-Like Growth Factor I
  • Metalloendopeptidases