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AIDS. 2000 Jul 28;14(11):1617-23.

Implementing short-course zidovudine to reduce mother-infant HIV transmission in a large pilot program in Thailand.

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  • 1Department of Health, Ministry of Public Health, Nonthaburi, Thailand.

Abstract

OBJECTIVES:

To describe a pilot mother-infant HIV prevention program started by the Ministry of Public Health of Thailand in July 1998 and to report on the first year of its implementation.

DESIGN:

Analysis of monthly summaries of data from project logbooks, simple data forms in antenatal clinics and delivery rooms, site visits and workshops, mail survey.

SETTING:

All 89 public hospitals in seven north-eastern provinces of Thailand.

PARTICIPANTS:

Childbearing women, program officials.

INTERVENTIONS:

Counseling and HIV testing for pregnant women, short-course antenatal zidovudine for HIV-infected pregnant women, and infant formula for their children.

MAIN OUTCOME MEASURES:

Proportion of women with HIV test, proportion of HIV-infected women receiving zidovudine.

RESULTS:

Of 75,308 women who gave birth between July 1998 and June 1999, 74,511 (98.9%) had antenatal care, 51,492 (69.1%) in the same district and 23,019 (30.9%) outside the district where they gave birth. HIV test results were available at delivery for 46,648 (61.9%) women, 410 (0.9%) of whom tested positive. Of these HIV-infected women, 259 (63.2%) participated in the zidovudine program and 6 (1.5%) received zidovudine from other sources. The proportion of women whose HIV test results were known and proportion of HIV-infected women who received zidovudine increased significantly during the year.

CONCLUSIONS:

A mother-infant HIV prevention program using short-course antenatal zidovudine was quickly implemented in a large region of Thailand with moderate HIV prevalence. This successful experience is leading to national implementation of a perinatal HIV prevention program in Thailand and may prompt other developing countries to start similar programs.

PMID:
10983649
[PubMed - indexed for MEDLINE]
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