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Nucleic Acids Res. 2000 Sep 15;28(18):3442-4.

STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene.

Author information

  • 1European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany. snel@embl-heidelberg.de

Abstract

The repeated occurrence of genes in each other's neighbourhood on genomes has been shown to indicate a functional association between the proteins they encode. Here we introduce STRING (search tool for recurring instances of neighbouring genes), a tool to retrieve and display the genes a query gene repeatedly occurs with in clusters on the genome. The tool performs iterative searches and visualises the results in their genomic context. By finding the genomically associated genes for a query, it delineates a set of potentially functionally associated genes. The usefulness of STRING is illustrated with an example that suggests a functional context for an RNA methylase with unknown specificity.

PMID:
10982861
[PubMed - indexed for MEDLINE]
PMCID:
PMC110752
Free PMC Article

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