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Curr Opin Genet Dev. 2000 Oct;10(5):555-61.

The role of chromosomal RNAs in marking the X for dosage compensation.

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  • 1Baylor College of Medicinem, Department of Molecular and Cellular Biology, One Baylor Plaza, Mail Stop BCM235, Houston, Texas 77030, USA.


Both flies and mammals remodel the architecture of the X chromosome to achieve dosage compensation. A novel class of noncoding RNAs that paint entire chromosomes are centrally involved in this process. The genes encoding these unusual RNAs are themselves located on the X, and are key sites that target the X for dosage compensation.

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