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    Am J Cardiol. 2000 Sep 15;86(6):703-5, A9.

    Influence of age and normal plasma fibrinogen levels on flow-mediated dilation in healthy adults.

    Allen JD, Wilson JB, Tulley RT, Lefevre M, Welsch MA.

    Department of Kinesiology and Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70803, USA.

    This study examined the effects of age-associated increases in fibrinogen on brachial artery flow-mediated dilation in 30 healthy nonsmokers. The findings demonstrate an inverse association between normal plasma fibrinogen levels and vascular function (r = -0.56, p = 0.001), suggesting elevated plasma fibrinogen may decrease the artery's responsiveness to certain vasodilatory signals, such as shear stress.

    PMID: 10980232 [PubMed - indexed for MEDLINE]

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